Figure 1

Effect of four different chemicals on inflammation-associated insulin signaling pathway in HepG2 cells. The QDot HCS assay was developed for various key kinases involved in inflammation-associated IR that are indicated with a red arrow and validated by specific inhibitors and anti-inflammatory drugs as shown. The p38α, JNK1, and IKKβ involved in the inflammatory pathway and IRS1ser307, IRS1tyr, FOXO1, and GSK3β associated with the insulin signaling pathway were simultaneously monitored by QDot multicolor cellular imaging.

© De Gruyter