Theranostics strategy based on plasmonic vesicles built of gold nanoparticles. (A) Scheme of the applied gold nanoparticles coated with mixed polymer brushes and a Raman reporter as well as the drug-loaded plasmonic vesicle coated with antibodies for cancer cell targeting. (B) Illustration of the plasmonic vesicle’s attachment to the outer cell membrane, their uptake and finally the disruption of the SERS-active, pH-sensitive vesicle structure. Reprinted with permission from Song et al. . Copyright 2012 American Chemical Society.