Figure 7

Flow-through plasmonic sensors are typically composed of a metallic layer supported by a thin film of silicon nitride, therefore it is possible to take advantage of the mixed materials to use material-specific chemistry to selectively functionalize only certain features of the nanoholes. In one example a suspended nanohole array composed of a Au layer on a Si3N4 thin film was functionalized with a biotinylated thiol, which is selectively immobilized on Au. Then the Si3N4 layer was passivated with a PEG layer [137].

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