Ultra-sensitive plasmonics for microfluidic sensing.
(A) A series of video snapshots to demonstrate the real-time sensing functionality of FlexBrite in microfluidics. In a microfluidic channel (width=500 μm) with FlexBrite in the bottom, glycerol is replaced with water (adapted from Ref.  with permission from The Royal Society of Chemistry). (B) Schematic of the microfluidic droplet generation nozzle region with top inlet for water and side inlets for oil (solid arrow indicates the direction of the flow); time-lapse reflection images of water (W) droplet formation, release, and re-formation in oil (O) emulsion at the nozzle region. (C) Streptavidin (SA)-biotin representative association curve on nanoLCA sensor immobilized with biotinylated thiol where two concentrations (100:1 and 200:1 dilution ratio) of streptavidin solution were used. BSA association curve on Au nanohole array sensor via adsorption (B and C reproduced from Ref.  under Creative Commons License). (D) Spectral blue shift from a high and low concentration of ebastine binding with immobilized CYP2J2-ND. Inset: Schematic of the CYP2J2-ND system with CYP2J2 protein (blue) incorporated into the nanodisk. The nanodisk consists of a phospholipid bilayer (gold) and two membrane scaffold proteins (red) (C and D adapted from Ref.  with permission from Elsevier).