Material substrates for cost-effective and portable biosensors.
(A) Photonic structure made by nanopillars of SU-8 resist on SiO2. (i) SEM image and (ii) schematic representation. Reprinted from Sensors Actuators B Chem, 176, Á. Lavín, R. Casquel, F.J. Sanza, M.F. Laguna, and M. Holgado, Efficient design and optimization of bio-photonic sensing cells (BICELLs) for label free biosensing, 753–760, Copyright (2013), with permission from Elsevier . (B) Photonic structures formed by Ag-coated nano-domes on flexible polyethylene terephthalate (PET) sheets. (i) SEM image; (ii) cross-section diagram; and (iii) image of the complete array substrate. Adapted from Ref. . Copyright IOP Publishing. Reproduced with permission. All rights reserved. (C) PC resonant reflector made by TiO2-coated UV-curable polymer. (i) SEM image; (ii) schematic of the substrate; and (iii) image of the array in standard microplate format. Adapted from Ref. , with permission of The Royal Society of Chemistry. (D) RPI sensing surface made by SiO2 anti-reflective layer on a glass slide. (i) RPI image of antibody spots with diameter of 150–200 μm; (ii) schematic of the sensing surface. Reprinted from Biosens Bioelectron, 74, M. Salina, F. Giavazzi, R. Lanfranco, E. Ceccarello, L. Sola, M. Chiari, B. Chini, R. Cerbino, T. Bellini, and M. Buscaglia, Multi-spot, label-free immunoassay on reflectionless glass, 539–545, Copyright (2015), with permission from Elsevier . (E) Array of plasmonic nano-holes integrated in microfluidic. (i) SEM image; (ii) schematic of the final fabrication step. Adapted by permission from Macmillan Publishers Ltd.: Scientific Reports , copyright 2014.