Figure 1:

Schematic illustration of the surface sensing of biomolecules by an optical fiber-based device coated with a nanometric scale overlay.

The biological recognition element (here drawn as an antibody) is covalently bound onto the functionalized surface of the overlay (wrinkled brown) leading to the formation of a sensing biolayer, and the specific target (ring-shaped pentameric antigen) will specifically interact with the recognition element, generating a change in the optical signal traveling in the fiber (white arrows). Any other non-specific biomolecules present in the complex matrix (e.g. serum albumin) will not bind to the receptor on the sensing layer, thus, not generating any change in the optical signal traveling in the fiber.

© De Gruyter