Figure 1:

In vitro toxic characterization has been tested in respect to proliferation, necrosis, apoptosis, DNA damage, and oxidative stress. Mice and rats would be more appropriate models due to their explicit genome for toxicity tests of organs including hepatic and renal, gastrointestinal, pulmonary, hematological, cardiovascular, nervous, reproductive, and immune systems in terms of histopathological changes and functions.

© De Gruyter