Applications of stem cell-derived exosomes in tissue engineering and neurological diseases
Baichuan Sun
/ Jiang Peng
/ Shoufeng Wang
/ Xuejian Liu
/ Kaihong Zhang
/ Zengzeng Zhang
/ Chong Wang
/ Xiaoguang Jing
/
Chengfu Zhou /
Yu Wang1
First Department of Orthopedics, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China
2
Institute of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China
3
Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226000, China
4
Beijing Key Laboratory of Regenerative Medicine in Orthopaedics, Beijing 100853, China
Cite as: Baichuan Sun, Jiang Peng, Shoufeng Wang, Xuejian Liu, et al. Applications of stem cell-derived exosomes in tissue engineering and neurological diseases, nano Online. (2019). DOI: https://doi.org/10.1515/nano.0103.00001
Cite as: Baichuan Sun, Jiang Peng, Shoufeng Wang, Xuejian Liu, et al.. Applications of stem cell-derived exosomes in tissue engineering and neurological diseases, Reviews in the Neurosciences. 29, 531 (2017). DOI: https://doi.org/10.1515/revneuro-2017-0059
Abstract
Exosomes are extracellular vesicles with diameters of 30–100 nm that are key for intercellular communication. Almost all types of cell, including dendritic cells, T cells, mast cells, epithelial cells, neuronal cells, adipocytes, mesenchymal stem cells, and platelets, can release exosomes. Exosomes are present in human body fluids, such as urine, amniotic fluid, malignant ascites, synovial fluid, breast milk, cerebrospinal fluid, semen, saliva, and blood. Exosomes have biological functions in immune response, antigen presentation, intercellular communication, and RNA and protein transfer. This review provides a brief overview of the origin, morphological characteristics, enrichment and identification methods, biological functions, and applications in tissue engineering and neurological diseases of exosomes.
Keywords: Spheres and Capsules; Organic, Biological and Biomimetic; Pharma and Medicine; Biotechnology; exosomes; extracellular vesicle; intercellular communication; neurological diseases; stem cell; tissue engineering
