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1 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
2 University of Science and Technology of China, Hefei 230026, P. R. China
3 Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, P. R. China
4 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China, Fax: +86-431-85262406
Quellenangabe: Yan Chen, Juan Wang, Jianhua Liu, Lehui Lu. Metal-Phenolic Encapsulated Mesoporous Silica Nanoparticles for pH-Responsive Drug Delivery and Magnetic Resonance Imaging, nano Online. (2019). DOI: https://doi.org/10.1515/nano.0048.00112
Quellenangabe: Yan Chen, Juan Wang, Jianhua Liu, Lehui Lu. Metal-Phenolic Encapsulated Mesoporous Silica Nanoparticles for pH-Responsive Drug Delivery and Magnetic Resonance Imaging, Zeitschrift für Physikalische Chemie. 232, 1733 (2018). DOI: https://doi.org/10.1515/zpch-2018-1145
The anticancer drug doxorubicin (DOX) is locked in the mesoporous silica nanoparticle by coating FeIII-TA polymer, and its burst release can be achieved under acidic environment, along with the decreased longitudinal relaxivity. This nanoplatform shows great potential to monitoring the drug delivery process and the fate of the nanocarrier.
Keywords: Metallic; Polymer; Oxides; Medical Diagnosis; Pharma and Medicine; drug delivery; magnetic resonance imaging; mesoporous silica nanoparticles
