Gold nanoparticle-based gene delivery: promises and challenges
1Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter Street, Columbia, SC 29208, USA
2Department of Chemical, Biological and Bioengineering, and Engineering Research Center- Revolutionized Metallic Biomaterials, North Carolina A&T State University, McNair 326, Greensboro, NC 27411, USA
Quellenangabe: Remant Bahadur K.C., Bindu Thapa, Narayan Bhattarai. Gold nanoparticle-based gene delivery: promises and challenges, nano Online. (2016). DOI: https://doi.org/10.1515/nano.0034.00081
Quellenangabe: Remant Bahadur K.C., Bindu Thapa, Narayan Bhattarai. Gold nanoparticle-based gene delivery: promises and challenges, Nanotechnology Reviews. 3, 269 (2013). DOI: https://doi.org/10.1515/ntrev-2013-0026
Abstract
Gold nanoparticles have emerged as a promising material for biomedical research due to ease of synthesis and highly adjustable optical properties, which can be utilized in the imaging of different diseases. Gold nanoparticles are fabricated by grafting biocompatible polymers and natural or synthethic biomolecules and present a novel avenue for engineering multifunctional smart systems. Many reports on the significant achievements and the bioconjugation chemistry promise to expand the application spectrum of gold nanoparticles. This review summarizes the current state-of-the-art development of functionalized gold nanoparticles for cancer gene therapy.
Keywords: bioconjugation; functionalization; gene delivery; gold nanoparticles
