Green processing of thermosensitive nanocurcumin-encapsulated chitosan hydrogel towards biomedical application
Thi Bich Tram Nguyen
1
/ Le Hang Dang
2
3
/ Thi Thanh Thuy Nguyen
2
/ Dai Lam Tran
4
/ Dai Hai Nguyen
2
/ Van Toan Nguyen
5
/ Cuu Khoa Nguyen
2
/ Thi Hiep Nguyen
6
/ Van Thu Le
7
/
Ngoc Quyen Tran
2
1Department of Natural Science, Thu Dau Mot University, Binh Dương, 590000, Viet Nam
2Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, 700000, Viet Nam
3School of Biotechnology, International University, Viet Nam National University in HCMC, 700000, Viet Nam
4Vietnam Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, 100000, Viet Nam
5Department of Chemistry and Food Technology, Ba Ria-Vung Tau University, Vung Tau City, 740000, Viet Nam
6Biomedical Engineering Department, International University, Viet Nam National University in HCMC, 700000, Viet Nam
7Institute of Chemistry-Biology and Professional Documents, Ministry of Public Security, Ha Noi, 100000, Viet Nam
Cite as: Thi Bich Tram Nguyen, Le Hang Dang, Thi Thanh Thuy Nguyen, Dai Lam Tran, et al. Green processing of thermosensitive nanocurcumin-encapsulated chitosan hydrogel towards biomedical application, nano Online. (2017). DOI: https://doi.org/10.1515/nano.0015.2016-0062
Cite as: Thi Bich Tram Nguyen, Le Hang Dang, Thi Thanh Thuy Nguyen, Dai Lam Tran, et al.. Green processing of thermosensitive nanocurcumin-encapsulated chitosan hydrogel towards biomedical application, Green Processing and Synthesis. 5, 511 (2016). DOI: https://doi.org/10.1515/gps-2016-0062
Abstract
In this study, in order to enhance the aqueous solubility and to overcome the limitation of curcumin (Cur) in free form, as well as to develop a carrier for transdermal delivery of hydrophobic pharmaceutical agents such as Cur, a sonicated synthetic process of nanocurcumin (nCur) in thermally responsive Chitosan-g-Pluronic (CP) copolymer is disclosed herein. The use of CP copolymer solution as a dispersant medium is a very attractive method to avoid the use of toxic organic solvent and non-biocompatible surfactant. The obtained Cur nanoparticles had a fairly narrow distribution of 8–23 nm. nCur-dispersed CP solution showed good stability with no change in color characteristic and no phase separation after 1 month of storage. Rheological characterization of CP hydrogels had indicated sol-gel transition at the same temperature (35°C). Interestingly, the rate of Cur release for this system can be conveniently modulated as transdermal drug delivery.
Keywords: biomedical application; chitosan; nanocurcumin; thermosensitive copolymer
