Endoscopic imaging using surface-enhanced Raman scattering
1
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
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Department of Nuclear Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea
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Department of Chemistry Education, Seoul National University, Seoul, Korea
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Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA
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Department of Bioscience and Biotechnology, Konkuk University, Seoul, Korea
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School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea
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Department of Chemistry Education, Seoul National University, 1 Gwanak-ro, Seoul 08826, Republic of Korea, Phone: +82-2-880-9258, Fax: +82-2-889-0749
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Department of Nuclear Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea, Phone: +82-2-2072-3920, Fax: +82-2-745-7690
9
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
Cite as: Yong-il Kim, Sinyoung Jeong, Bong-Hyun Jun, Yun-Sang Lee, et al. Endoscopic imaging using surface-enhanced Raman scattering, nano Online. (2018). DOI: https://doi.org/10.1515/nano.0012.00073
Cite as: Yong-il Kim, Sinyoung Jeong, Bong-Hyun Jun, Yun-Sang Lee, et al.. Endoscopic imaging using surface-enhanced Raman scattering, European Journal of Nanomedicine. 9, 91 (2017). DOI: https://doi.org/10.1515/ejnm-2017-0005
Abstract
In this review, we assessed endoscopic imaging using surface-enhanced Raman scattering (SERS). As white-light endoscopy, the current standard for gastrointestinal endoscopy, is limited to morphology, Raman endoscopy using surface-enhanced Raman scattering nanoparticles (SERS endoscopy) was introduced as one of the novel functional modalities. SERS endoscopy has multiplex capability and high sensitivity with low autofluorescence and photobleaching. As a result, multiple molecular characteristics of the lesion can be accurately evaluated in real time while performing endoscopy using SERS probes and appropriate instrumentation. Especially, recently developed dual modality of fluorescence and SERS endoscopy offers easy localization with identification of multiple target molecules. For clinical use of SERS endoscopy in the future, problems of limited field of view and cytotoxicity should be addressed by fusion imaging, topical administration, and non-toxic coating of nanoparticles. We expect SERS endoscopic imaging would be an essential endoscopic technique for diagnosis of cancerous lesions, assessment of resection margins and evaluation of therapeutic responses.
Keywords: endoscopy; nanoparticles; Raman spectroscopy; surface-enhanced Raman scattering
