Multifunctional graphene oxide for bioimaging: emphasis on biological research
1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
2Medical Research Center, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
3Department of Chemistry, Seoul National University, Seoul, Korea
4Department of Nuclear Medicine, Seoul National University Hospital, 28 Yongon-Dong, Jongno-Gu, Seoul 110-744, Korea
5Seoul National University College of Medicine, Seoul, Korea
6Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul, Korea
Cite as: Do Won Hwang, Byung Hee Hong, Dong Soo Lee. Multifunctional graphene oxide for bioimaging: emphasis on biological research, nano Online. (2018). DOI: https://doi.org/10.1515/nano.0012.00070
Cite as: Do Won Hwang, Byung Hee Hong, Dong Soo Lee. Multifunctional graphene oxide for bioimaging: emphasis on biological research, European Journal of Nanomedicine. 9, 47 (2017). DOI: https://doi.org/10.1515/ejnm-2016-0036
Abstract
Graphene oxide (GO) nanomaterials offer a wide range of bioimaging applicability. Almost complete quenching ability of fluorescence by GO and natural interaction of GO with single stranded nucleic acid made GO a useful and intriguing multifunctional nanoplatform both as a biosensor for in vitro microplate diagnostics and as a drug delivery carrier for targeted delivery. GO’s large surface area and strong near infrared absorbance contribute to enhancement of a therapeutic effect with abundant loading of drugs for possible photothermal and photodynamic therapy. Bioimaging capability of GO made it a good theranostic tool, while enabling tracing in vivo pharmacokinetics during concurrent treatment. Fluorescence, either signal on or off, Raman and surface-enhanced Raman scattering (SERs), photoacoustic, and radionuclide imaging modalities can be used for theranostic purposes using GO nanomaterials. In this review, we highlight current applications of GO for bioimaging that are classified into in vitro microplate, in vitro cellular and in vivo bioimaging.
Keywords: bioimaging; cellular bioimaging; graphene oxide; in vitro diagnosis; in vivo theranostics
