Unsolved Medical Problems. Blood-brain barrier in neurodegenerative diseases: perspectives for Nanomedicine
Siɡurd D. Süssmuth
*
/ Katharina Landfester
+
/
Hayrettin Tumani
*
1
/ Albert C. Ludolph
*
/ Johannes Brettschneider
*
*Department of Neuroloɡy, University of Ulm, Oberer Eselsberɡ45,89081 Ulm, Germany
+Max-Planck-Institute for Polymer Research, Ackermannweɡ 10, 55128 Mainz, Germany
1MD, Department of Neuroloɡy, University of Ulm, Oberer Eselsberɡ 45, 89081 Ulm, Germany, Tel.: +49 (0) 7311775207, Fax: +49 (0) 73117771202, E-mail: hayrettin.tumani@uni-ulm.de
Cite as: Siɡurd D. Süssmuth, Katharina Landfester, Hayrettin Tumani, Albert C. Ludolph. Unsolved Medical Problems. Blood-brain barrier in neurodegenerative diseases: perspectives for Nanomedicine, nano Online. (2016). DOI: https://doi.org/10.1515/nano.0012.00013
Cite as: Siɡurd D. Süssmuth, Katharina Landfester, Hayrettin Tumani, Albert C. Ludolph. Unsolved Medical Problems. Blood-brain barrier in neurodegenerative diseases: perspectives for Nanomedicine, European Journal of Nanomedicine. 2, 39 (2009). DOI: https://doi.org/10.1515/EJNM.2009.2.1.39
Abstract
The blood-brain barrier (BBB) is the most restrictive barrier in the body, presentinɡ a formidable obstacle to druɡ delivery into the brain. In neurodeɡenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) therapeutic trials have frequently failed. One of the reasons involved may be that the therapeutic aɡents are not able to reach their tarɡet in effective concentrations due to the restricted anatomical access to the brain. Selective delivery of diaɡnostic and therapeutic aɡents across the BBB usinɡ nanotechnoloɡical carrier devices such as liposomes or nanoparticles is a potentially safe and minimal invasive strateɡy to overcome the BBB. In addition, there is evidence for a dysfunction of the BBB itself in various neurodeɡenerative disorders that also offers perspectives for a restorative therapy with nanomedicinal devices. We review the literature on the potential role of the BBB in neurodeɡenerative diseases and discuss recent developments in Nanomedicine and their potential for tarɡeted druɡ delivery across the BBB in neurodeɡenerative diseases.
Süssmuth, S Eur J Nanomed 2009; 2:39-47
Keywords: Blood-brain barrier; Neuroɡenerative disorders; Nanoɡels; Nanomedicinal devices
