Gold nanoparticles in the clinical laboratory: principles of preparation and applications
1Yousef Jameel Science and Technology Research Center, The American University in Cairo, New Cairo, Egypt
2Department of Chemistry, The American University in Cairo, New Cairo, Egypt
*Corresponding author: Dr. Hassan M.E. Azzazy, The American University in Cairo, P.O. Box 74, New Cairo, 11835, Egypt Phone: +202 2615-2559, Fax: +202 2795 7565, E-mail: hazzazy@aucegypt.edu
3Faculty of Pharmacy, Misr University for Science and Technology, October City, Egypt
4REQUIMTE, Departmento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Campus de Caparica, Lisboa, Portugal
Cite as: Hassan M.E. Azzazy, Mai M.H. Mansour, Tamer M. Samir, Ricardo Franco.
Gold nanoparticles in the clinical laboratory: principles of preparation and applications, nano Online. (2016). DOI: https://doi.org/10.1515/nano.0008.00003
Cite as: Hassan M.E. Azzazy, Mai M.H. Mansour, Tamer M. Samir, Ricardo Franco.
Gold nanoparticles in the clinical laboratory: principles of preparation and applications, Clinical Chemistry and Laboratory Medicine. 50, 193 (2012). DOI: https://doi.org/10.1515/cclm.2011.732
Abstract
In order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysical properties which enable sensitive detection of biomarkers, and are easily amenable to modification for use in different assay formats including immunoassays and molecular assays. Additionally, their preparation is relatively simple and their detection methods are quite versatile. AuNPs are showing substantial promise for effective practical applications and commercial utilization is already underway. This article covers the principles of preparation of AuNPs and their use for development of different diagnostic platforms.
Keywords: assay; bio-barcode; diagnostics; gold nanoparticles; immunoassay; molecular assay; nanomedicine
