Antibacterial polyamides based on a dendritic zinc-hybrid with good biocompatibility showing reduced biofilm formation
Michael Gladitz
1
/ Janine Bauer
1
/ Peggy Brückner
1
/
Stefan Reinemann
1
/ Cornelia Wiegand
2
/ Michael Zieger
2
/ Kirsten Reddersen
2
/ Uta-Christina Hipler
2
/ Marion Frant
3
/ Klaus Liefeith
3
/ Hans-Joachim Radusch
4
1Thuringian Institute of Textile and Plastics Research, Department of Plastics Research, 07407 Rudolstadt, Germany
2Department of Dermatology, University Medical Center, 07740 Jena, Germany
3Institute for Bioprocessing and Analytical Measurement Techniques, Department Biomaterials, 37308 Heilbad Heiligenstadt, Germany
4Center of Engineering Sciences, Martin Luther University Halle-Wittenberg, 06099 Halle/Saale, Germany
Quellenangabe: Michael Gladitz, Janine Bauer, Peggy Brückner, Stefan Reinemann, et al. Antibacterial polyamides based on a dendritic zinc-hybrid with good biocompatibility showing reduced biofilm formation, nano Online. (2016). DOI: https://doi.org/10.1515/nano.0005.00019
Quellenangabe: Michael Gladitz, Janine Bauer, Peggy Brückner, Stefan Reinemann, et al.. Antibacterial polyamides based on a dendritic zinc-hybrid with good biocompatibility showing reduced biofilm formation, BioNanoMaterials. 15, 31 (2014). DOI: https://doi.org/10.1515/bnm-2014-0009
Abstract
Antimicrobial organic-inorganic hybrids based on amphiphilic dendritic hyperbranched polyethylenimine with zinc were prepared. To study their property profile and potential as an antimicrobial modifier they were incorporated via melt extrusion into cast films or injection molded into plates of polyamide (PA). The antimicrobial efficacy, bacterial adhesion, cytotoxicity and blood compatibility of the respective PA composites were investigated as a function of material composition and morphology. It could be demonstrated that the polymers with the developed zinc-hybrids possess a high antimicrobial efficacy as well as good cyto- and hemo-compatibility in vitro. Furthermore, they showed reduced bacterial adhesion. Finally, it can be stated that the developed zinc-hybrids are suitable as advanced additive agents for the production of antimicrobial polymer materials with promising properties particular for various medical applications.
Keywords: antibacterial polyamide; bioadhesion; biocompatibility; functionalization of polyethylenimine; hyperbranched polymers; zinc
